Recombinant Human CD80 Molecule, Fc-Tagged

Specification :
| Cat. No. : CD80-54H | Description : B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulateT- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 – 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. A DNA sequence encoding the extracellular domain ( Met 1- Asn 242 ) of human B7-1 (NP_005182.1) precursor was fused with the C-terminal His-tagged Fc region of human IgG1 at the C-terminus. | Predicted N terminal : Val 35 | Purity : > 95%, as determined by SDS-PAGE | Endotoxin : | Formulation : Supplied as a 0.2μm filtered solution of PBS, pH7.4 | Reconstitution : Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents. | Stability : Samples are stable for up to twelve months from date of receipt -70°C | Storage : Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage and be used as soon as possible. Avoid repeated freeze-thaw cycles.