Name :
Recombinant Human CD8b, His-tagged
Specification :
| Description : CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. | Source : E. coli | Species : Human | Tag : His | Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol | Molecular Mass : 19.2kDa (172aa) | AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSSDSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SP | Purity : >80% by SDS – PAGE | Applications : SDS-PAGE | Storage : Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles. | Concentration : 0.5 mg/ml (determined by Bradford assay)
Gene Information :
| Gene Name : CD8b CD8b molecule [ Homo sapiens ] | Official Symbol : CD8b | Synonyms : CD8b; CD8b molecule; CD8 antigen, beta polypeptide 1 (p37) , CD8b1; T-cell surface glycoprotein CD8 beta chain; CD8 antigen, beta polypeptide 1 (p37); T lymphocyte surface glycoprotein beta chain; LY3; P37; LEU2; LYT3; CD8b1; MGC119115; | Gene ID : 926 | mRNA Refseq : NM_001178100 | Protein Refseq : NP_001171571 | MIM : 186730 | UniProt ID : P10966 | Chromosome Location : 2p12 | Pathway : Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Disease, organism-specific biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; | Function : MHC class I protein binding; coreceptor activity; protein binding;
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