Name :
Recombinant Human CLEC7A, His-tagged
Specification :
| Description : This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. | Source : E.coli | Species : Human | Tag : His | Protein length : 1-77a.a. | Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. | Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Information :
| Gene Name : CLEC7A C-type lectin domain family 7, member A [ Homo sapiens ] | Official Symbol : CLEC7A | Synonyms : CLEC7A; C-type lectin domain family 7, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12 , CLECSF12; C-type lectin domain family 7 member A; dectin 1; hDectin 1; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; BGR; CANDF4; DECTIN1; CLECSF12; | Gene ID : 64581 | mRNA Refseq : NM_022570 | Protein Refseq : NP_072092 | MIM : 606264 | UniProt ID : Q9BXN2 | Chromosome Location : 12p13.2-p12.3 | Pathway : Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem; | Function : (1->3)-beta-D-glucan binding; MHC protein binding; binding; metal ion binding; opsonin binding; pattern recognition receptor activity; sugar binding; sugar binding;
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