Recombinant Human CLEC7A Protein, His-tagged

Specification :
| Description : Dectin-1 is a C-type lectin receptor expressed by macrophages, monocytes, dendrtic cells, neutrophils, and a subset of γδ T cells. Dectin-1 is a glycoprotein with eight different isoforms, generated through alternative splicing. It plays an important role in anti-fungal immunity by acting as a pattern recognition receptor for β-glucans found on the cell wall of fungi and some bacteria. Dectin-1 is composed of a short amino-terminal cytoplasmic domain containing an ITAM-like motif, a transmembrane domain, and an extracellular carboxy-terminal C-type lectin domain. Dectin-1 recognizes β-glucans through its C-type lectin domain and transduces signals through its ITAM-like motif by recruiting and activating Syk. Dendritic cells activated through Dectin-1 promote differentiation of Th17 cells by producing IL-6 and IL-23. | Source : E. coli | Species : Human | Tag : His | Molecular Mass : ~21 kDa | AA Sequence : TMAIWRSNSGSNTLENGYFLSRNKE NHSQPTQSSLEDSVTPTKAVKTTGV LSSPCPPNWIIYEKSCYLFSMSLNS WDGSKRQCWQLGSNLLKIDSSNELG FIVKQVSSQPDNSFWIGLSRPQTEV PWLWEDGSTFSSNLFQIRTTATQEN PSPNCVWIHVSVIYDQLCSVPSYSI CEKKFSM | Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). | Notes : For research use only, not for use in diagnostic procedure. | Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. | Concentration : ≥0.5 mg/mL | Storage Buffer : PBS, 4M Urea, pH7.4