Recombinant Human CLK2 Protein, GST-tagged

Specification :
| Description : This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] | Source : Wheat Germ | Species : Human | Tag : GST | Molecular Mass : 80.52 kDa | AA Sequence : MPHPRRYHSSERGSRGSYREHYRSR KHKRRRSRSWSSSSDRTRRRRREDS YHVRSRSSYDDRSSDRRVYDRRYCG SYRRNDYSRDRGDAYYDTDYRHSYE YQRENSSYRSQRSSRRKHRRRRRRS RTFSRSSSHSSRRAKSVEDDAEGHL IYHVGDWLQERYEIVSTLGEGTFGR VVQCVDHRRGGARVALKIIKNVEKY KEAARLEINVLEKINEKDPDNKNLC VQMFDWFDYHGHMCISFELLGLSTF DFLKDNNYLPYPIHQVRHMAFQLCQ AVKFLHDNKLTHTDLKPENILFVNS DYELTYNLEKKRDERSVKSTAVRVV DFGSATFDHEHHSTIVSTRHYRAPE VILELGWSQPCDVWSIGCIIFEYYV GFTLFQTHDNREHLAMMERILGPIP SRMIRKTRKQKYFYRGRLDWDENTS AGRYVRENCKPLRRYLTSEAEEHHQ LFDLIESMLEYEPAKRLTLGEALQH PFFARLRAEPPNKLWDSSRDISR | Applications : Kinase Assay enlargeEnzyme-linked Immunoabsorbent AssayWestern Blot (Recombinant protein)Antibody ProductionProtein Array | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.