Recombinant Human CSF1R Protein, Fc-tagged

Specification :
| Description : The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. | Source : HEK293 | Species : Human | Tag : Fc | Form : Lyophilized | Molecular Mass : 80.7 kDa | Protein Length : 972 | AA Sequence : MGPGVLLLLLVATAWHGQGIPVIEP SVPELVVKPGATVTLRCVGNGSVEW DGPPSPHWTLYSDGSSSILSTNNAT FQNTGTYRCTEPGDPLGGSAAIHLY VKDPARPWNVLAQEVVVFEDQDALL PCLLTDPVLEAGVSLVRVRGRPLMR HTNYSFSPWHGFTIHRAKFIQSQDY QCSALMGGRKVMSISIRLKVQKVIP GPPALTLVPAELVRIRGEAAQIVCS ASSVDVNFDVFLQHNNTKLAIPQQS DFHNNRYQKVLTLNLDQVDFQHAGN YSCVASNVQGKHSTSMFFRVVESAY LNLSSEQNLIQEVTVGEGLNLKVMV EAYPGLQGFNWTYLGPFSDHQPEPK LANATTKDTYRHTFTLSLPRLKPSE AGRYSFLARNPGGWRALTFELTLRY PPEVSVIWTFINGSGTLLCAASGYP QPNVTWLQCSGHTDRCDEAQVLQVW DDPYPEVLSQEPFHKVTVQSLLTVE TLEHNQTYECRAHNSVGSGSWAFIP ISAGAHTHPPDEFLFTPVVVACMSI MALLLLLLLLLLYKYKQKPKYQVRW KIIESYEGNSYTFIDPTQLPYNEKW EFPRNNLQFGKTLGAGAFGKVVEAT AFGLGKEDAVLKVAVKMLKSTAHAD EKEALMSELKIMSHLGQHENIVNLL GACTHGGPVLVITEYCCYGDLLNFL RRKAEAMLGPSLSPGQDPEGGVDYK NIHLEKKYVRRDSGFSSQGVDTYVE MRPVSTSSNDSFSEQDLDKEDGRPL ELRDLLHFSSQVAQGMAFLASKNCI HRDVAARNVLLTNGHVAKIGDFGLA RDIMNDSNYIVKGNARLPVKWMAPE SIFDCVYTVQSDVWSYGILLWEIFS LGLNPYPGILVNSKFYKLVKDGYQM AQPAFAPKNIYSIMQACWALEPTHR PTFQQICSFLQEQAQEDRRERDYTN LPSSSRSGGSGSSSSELEEESSSEH LTCCEQGDIAQPLLQPNNYQFC | Purity : > 98% | Applications : WB; ELISA; FACS; FC | Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. | Storage : At -20 centigrade. | Concentration : 1 mg/mL | Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution. | Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.