Product: AP08502PU-N11-beta HSD2 / HSD11B2 (25-40) antibody
Quantity: 50 µg
Synonyms: 11-DH2, 11-beta-hydroxysteroid dehydrogenase 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, HSD11K, NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Presentation: Aff – Purified
Clonality: Polyclonal
Host: Rabbit
Isotype: IgG
CAS NO: 3546-41-6 Product: Pyrvinium pamoate
Shipping to: Worldwide
Immunogen: Synthetic peptide corresponding to amino acids 25-40 of human 11 beta-HSD2AA Sequence:RSDLRLGRPLLAALALGeneID:3291Remarks:Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat (100%); Marmoset, Sheep, Bat, Bovine, Rabbit, Pig (94%)
Application: Western blot: 1/200.Immunohistochemistry on Paraffin sections: 10 µg/ml; Heat induced antigen retrieval in pH 6.0 citrate buffer is recommended.
Background: HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. The protein modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.Defects in HSD11B2
Concentration: 1.0 mg/ml
Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.Avoid repeated freezing and thawing.Shelf life: one year from despatch.
Buffer System: TBS
Preservatives:
State: Liquid purified Ig fractionAff – Purified
Specifictiy: This antibody recognizes 11-HSD2 at aa 25-40.
