Name :
Recombinant Human CTLA4, Fc-tagged therapeutic protein
Specification :
| Description : This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. | Source : CHO | Species : Human | Tag : Fc | Molecular Mass : 92.3 kDa (with glycosylation) | AA Sequence : MHVAQPAVVLASSRGIASFVCEYAS PGKATEVRVTVLRQADSQVTEVCAA TYMMGNELTFLDDSICTGTSSGNQV NLTIQGLRAMDTGLYICKVELMYPP PYYLGIGNGTQIYVIDPEPCPDSDQ EPKSSDKTHTSPPSPAPELLG GSSVFLFPPKPKDTLMISRTPEVTC VVVDVSHEDPEVKFNWYVDGVEVHN AKTKPREEQYNSTYRVVSVLTVLHQ DWLNGKEYKCKVSNKALPAPIEKTI SKAKGQPREPQVYTLPPSRDELTKN QVSLTCLVKGFYPSDIAVEWE SNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEAL HNHYTQKSLSLSPGK | Endotoxin : | Purity : >98%
Gene Information :
| Gene Name : CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ] | Official Symbol : CTLA4 | Synonyms : CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3 , CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; GRD4; CTLA-4; IDDM12; CELIAC3; | Gene ID : 1493 | mRNA Refseq : NM_001037631 | Protein Refseq : NP_001032720 | UniProt ID : P16410 | Chromosome Location : 2q33 | Pathway : Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; | Function : protein binding;
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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