Recombinant Human Cytotoxic T-lymphocyte-associated Protein 4, Fc-His

Specification :
| Cat. No. : CTLA4-1598H | Description : CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system. CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells. CTLA4 is potentially therapeutic in auto-immune diseases, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. | Molecular Weight : The predicted molecular weight of Recombinant Human CTLA-4 is Mr 40 kDa. | Source : Sf 21 Insect Cells. | State Of Matter : Lyophilized. | Purity : >90% by SDS Page and analyzed by silver stain | Endotoxin : | Biological Activity : The biological activity of Human CTLA-4 was determined by its ability to inhibit IL-2 production by Jurkat cells stimulated with Raji cells or 1 μg/ml rhB7-1/Fc in the presence of PHA. The expected ED50 is typically 2 – 4 μg/ml with Raji cells or 0.1 – 0.4 μg/ml with rhB7-H1/Fc. | Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.