Recombinant Human DDR1 Protein

Specification :
| Description : Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] | Source : Wheat Germ | Species : Human | Form : Liquid | Molecular Mass : 97.2 kDa | AA Sequence : MGPEALSSLLLLLLVASGDADMKGH FDPAKCRYALGMQDRTIPDSDISAS SSWSDSTAARHSRLESSDGDGAWCP AGSVFPKEEEYLQVDLQRLHLVALV GTQGRHAGGLGKEFSRSYRLRYSRD GRRWMGWKDRWGQEVISGNEDPEGV VLKDLGPPMVARLVRFYPRADRVMS VCLRVELYGCLWRDGLLSYTAPVGQ TMYLSEAVYLNDSTYDGHTVGGLQY GGLGQLADGVVGLDDFRKSQELRVW PGYDYVGWSNHSFSSGYVEMEFEFD RLRAFQAMQVHCNNMHTLGARLPGG VECRFRRGPAMAWEGEPMRHNLGGN LGDPRARAVSVPLGGRVARFLQCRF LFAGPWLLFSEISFISDVVNNSSPA LGGTFPPAPWWPPGPPPTNFSSLEL EPRGQQPVAKAEGSPTAILIGCLVA IILLLLLIIALMLWRLHWRRLLSKA ERRVLEEELTVHLSVPGDTILINNR PGPREPPPYQEPRPRGNPPHSAPCV PNGSAYSGDYMEPEKPGAPLLPPPP QNSVPHYAEADIVTLQGVTGGNTYA VPALPPGAVGDGPPRVDFPRSRLRF KEKLGEGQFGEVHLCEVDSPQDLVS LDFPLNVRKGHPLLVAVKILRPDAT KNARNDFLKEVKIMSRLKDPNIIRL LGVCVQDDPLCMITDYMENGDLNQF LSAHQLEDKAAEGAPGDGQAAQGPT ISYPMLLHVAAQIASGMRYLATLNF VHRDLATRNCLVGENFTIKIADFGM SRNLYAGDYYRVQGRAVLPIRWMAW ECILMGKFTTASDVWAFGVTLWEVL MLCRAQPFGQLTDEQVIENAGEFFR DQGRQVYLSRPPACPQGLYELMLRC WSRESEQRPPFSQLHRFLAEDALNT V | Applications : Antibody ProductionFunctional StudyCompound Screening | Usage : Heating may cause protein aggregation. Please do not heat this product before electrophoresis. | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.