Recombinant Human DDR2 Protein, C-His-tagged

Specification :
| Description : The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2. They are widely expressed in human tissues and may have roles in smooth muscle cell-mediated collagen remodeling. Research studies have implicated aberrant expression and signaling of DDRs in human diseases related to increased matrix degradation and remodeling, such as cardiovascular disease, liver fibrosis, and tumor invasion. Injection of colon tumor cells into DDR2 knock out mice predisposes the hepatic stellate cells to colon tumor metastasis. | Source : E. coli | Species : Human | Tag : C-His | Molecular Mass : ~42 kDa | AA Sequence : KAQVNPAICRYPLGMSGGQIPDEDI TASSQWSESTAAKYGRLDSEEGDGA WCPEIPVEPDDLKEFLQIDLHTLHF ITLVGTQGRHAGGHGIEFAPMYKIN YSRDGTRWISWRNRHGKQVLDGNSN PYDIFLKDLEPPIVARFVRFIPVTD HSMNVCMRVELYGCVWLDGLVSYNA PAGQQFVLPGGSIIYLNDSVYDGAV GYSMTEGLGQLTDGVSGLDDFTQTH EYHVWPGYDYVGWRNESATNGYIEI MFEFDRIRNFTTMKVHCNNMFAKGV KIFKEVQCYFRSEASEWEPNAISFP LVLDDVNPSARFVTVPLHHRMASAI KCQYHFADTWMMFSEITFQSDAAMY NNSEALPTSPMAPTTYDPMLKVDDS NTR | Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). | Notes : For research use only, not for use in diagnostic procedure. | Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. | Concentration : ≥0.5 mg/mL | Storage Buffer : PBS, 4M Urea, pH7.4