Active Recombinant Human EGFR Protein, His-tagged

Specification :
| Description : As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. | Source : CHO | Species : Human | Tag : His | Predicted N Terminal : Leu 25 | Form : Lyophilized from sterile PBS, pH 7.4 | Bio-activity : Measured by its binding ability in a functional ELISA. | Molecular Mass : The recombinant mature human EGFR protein consists of 629 amino acids and has a calculated molecular mass of 69.6 KD. | Protein length : 25-647 aa | Endotoxin : | Purity : >95%(SDS-PAGE) | Stability : Stable for up to twelve months from date of receipt at -70 centigrade | Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.