Share this post on:

Name :
Recombinant Human ERBB2 protein, Fc-tagged

Specification :
| Description : Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2/neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation . | Source : HEK293 | Species : Human | Tag : mouse IgG2a Fc | Predicted N Terminal : Thr23 | Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. | Molecular Mass : The protein has a calculated MW of 96.2 kDa. The protein migrates as 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. | Protein length : Thr23-Thr652 | Endotoxin : Less than 0.1 EU per μg by the LAL method. | Purity : >95% as determined by SDS-PAGE. | Storage : For long term storage, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles.This product is stable after storage at:-20°C to -70°C for 12 months in lyophilized state;-70°C for 3 months under sterile conditions after reconstitution. | Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information :
| Gene Name : ERBB2 | Official Symbol : ERBB2 | Synonyms : ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1 | Gene ID : 2064 | mRNA Refseq : NM_004448.4 | Protein Refseq : NP_004439.2 | MIM : 164870 | UniProt ID : P04626

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
TREM2 ProteinMolecular Weight
Delta-like protein 1/DLL1 Proteincustom synthesis
Popular categories:
CEA Cell Adhesion Molecule 6 (CEACAM6)
I-TAC/CXCL11

Share this post on:

Author: Cholesterol Absorption Inhibitors