Recombinant Human F11 Receptor, His-tagged

Specification :
| Cat. No. : F11R-788H | Description : As a typeⅠtransmembrane receptor belonging to the immunoglobulin superfamily, the human JAM-A, also known as platelet adhesion molecule 1(PAM-1) and platelet F11 receptor, is the firstly identified member of the Junctional Adhesion Molecule (JAM) family comprising at least three members. JAM-A is specifically localized in tight junctions of epithelial and endothelial cells and is involved in the regulation of junctional integrity and permeability by serving as a physical barrier in a homophilic manner. JAM-A is also expressed on the surface of hematopoeitic cells, such as platelets and leukocytes, and acts as a ligand for Integrin LFA-1 or a platelet receptor, consequently plays key roles in a variety of cellular processes, including platelet aggregation, leukocyte transmigration, and angiogenesis. In addition, JAM-A has also been implicated in the attachment of reovirus that causes diarrhea in human. | Source : Human Cells. | Molecular Mass : The mature recombinant human JAM-A/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer comprises 453 amino acids and has a calculated molecular mass of 50 kDa. As a result of glycosylation, the rh JAM-A/Fc monomer migrates as an approximately 61kDa protein in SDS-PAGE under reducing conditions. | Predicted N Terminal : Ser 28. | Purity : > 95% as determined by SDS-PAGE. | Formulation : Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH7.5. | Endotoxin : | Reconstitution : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. | Storage And Stability : Samples are stable for up to twelve months from date of receipt at -700C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.