Name :
Recombinant Human Fas Ligand (TNF superfamily, member 6)
Specification :
| Cat. No. : FASLG-5413H | Description : FASLG is a type-II transmembraneprotein that belongs to the tumor necrosis factor (TNF) family. Its bindingwith its receptor induces apoptosis. Fas ligand/receptor interactions play animportant role in the regulation of the immune system and the progression ofcancer. | Source : CHO cells | Species : Human | Form : Lyophilized withoutadditives. | Molecular Weight : 19.9 kDa | Purity : >98% asdetermined by SDS-PAGE analysis. | Endotoxin Level : | Biological Activity : Determined by itsability to induce cytotoxicity in Jurkat cells in the absence of anycross-linking. The EDSO for this effect is | Specific Activity : >2 x 105units/mg | Reconstitution : Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-1.0 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions. | Storage : Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C.Avoid repeated freeze-thaw cycles. | OfficialSymbol : FASLG
Gene Information :
| Gene Name : FASLG Fas ligand (TNFsuperfamily, member 6) [ Homo sapiens ] | Synonyms : FASLG; Fas ligand(TNF superfamily, member 6); FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1; tumor necrosis factor ligand superfamily member 6; APTL; CD95ligand; OTTHUMP00000032708; fas antigen ligand; apoptosis antigen ligand;apoptosis (APO-1) antigen ligand 1; tumor necrosis factor (ligand)superfamily, member 6 | Gene ID : 356 | mRNA Refseq : NM_000639 | Protein Refseq : NP_000630 | MIM : 134638 | UniProt ID : P48023 | Chromosome Location : 1q23 | Pathway : Activationof Pro-Caspase 8; Africantrypanosomiasis; Allograft rejection;Apoptosis; Autoimmune thyroid disease; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+ TCR pathway; Caspase-8 is formed from proCaspase-8; Death Receptor Signalling; FoxO family signaling; Influenza A; MAPKsignaling pathway; Measles; Pathways in cancer; Type I diabetes mellitus | Function : cytokine activity;protein binding; receptor binding; tumor necrosis factor receptor binding
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