Recombinant Human Fas (TNF Receptor Ssuper Family, Member 6)

Specification :
| Cat. No. : FAS-1411H | Description : Apo-1 (Fas/CD95) is a 45 kD type I transmembrane protein belonging to the TNF receptor family. A subgroup of this receptor family called ”death receptors” contain 3-4 cysteine-rich repeats in the extracellular portion and a cystoplasmic motif called the ”death domain”, which is responsible for the transduction of the death signal. The death domain associates with FADD/MORT, which in turn connects to aspartate-specific proteases (Caspases) that are implicated as mediators of most types of apoptotic cell death (6-9). | Source : Human embryo kidney cells. | Presentation And Handling : sAPO-1/Fas is provided as lyophilized powder. Prepare a concentrated stock solution of APO-1/Fas:Fc-IgG (1 mg/ml in PBS) by dissolving the entire preparation (50 µg) in 50 µl sterile H2O. Further dilutions should be made with medium containing 5% fetal calf serum. | Purity : >95% pure as demonstrated by SDS-PAGE. | Biological Activity : Recombinant, human soluble APO-1/Fas:Fc-IgG inhibits the activity of APO-1/Fas ligand of human and mouse.