Recombinant Human FCGR3A Protein, ECD, Tag Free, Biotinylated

Specification :
| Description : This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. | Source : HEK293 | Species : Human | Tag : Tag Free | Protein length : ECD | Conjugation/Label : Biotin | Form : Lyophilised | Endotoxin : Endotoxin level was found to be less than 0.1 ng/μg (1 EU/μg). | Applications : ELISA, WB | Notes : FOR RESEARCH USE ONLY (RUO). | Storage : Recombinant CD16a, as supplied, can be stored in working aliquots at 2 to 8 centigrade for one month, or at -20 to -70 centigrade for 1 year. Avoid repeated freeze/thaw cycles. | Storage Buffer : Lyophilised from 0.2 μm filtered PBS solution, pH 7.2. | Reconstitution : Upon receipt a quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL.