Active Recombinant Human FCGR2A (R167H) Protein (30-218aa), C-His-tagged

Specification :
| Description : Fc gamma RIIA/CD32a, also known as Low affinity immunoglobulin gamma Fc region receptor II-a, are members of the Ig superfamily that function in the activation or inhibition of immune responses. Fc gamma RIIA is expressed on many immune cell types where inhibitory ITIM-bearing receptors may also be co-expressed and co_x005f_x0002_engaged by specific ligands. Signaling through Fc gamma RIIA results in the initiation of inflammatory responses that can be modulated by signals from the inhibitory receptors. The strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors. Besides IC, Fc gamma RII A also binds C-reactive protein (CRP) Two allelic variants of Fc gamma RIIA that differ in their ability to ligate human IgG2 or CRP exist. The R167H allele has been found to have a protective effect against lupus nephritis. | Source : HEK293 | Species : Human | Tag : C-His | Form : Liquid | Bio-activity : Measured by its binding ability in a functional ELISA with Human IgG1 Fc. The ED50 range ≤5 μg/mL. | Molecular Mass : 21.6 kDa (195 aa) | Protein Length : 30-218 aa | AA Sequence : SADSQAAAPPKAVLKLEPPWINVLQ EDSVTLTCQGARSPESDSIQWFHNG NLIPTHTQPSYRFKANNNDSGEYTC QTGQTSLSDPVHLTVLSEWLVLQTP HLEFQEGETIMLRCHSWKDKPLVKV TFFQNGKSQKFSHLDPTFSIPQANH SHSGDYHCTGNIGYTLFSSKPVTIT VQVPSMGSSSPMGI | Endotoxin : | Purity : > 95% by SDS-PAGE | Applications : SDS-PAGE, Bioactivity | Notes : For research use only. This product is not intended or approved for human, diagnostics or veterinary use. | Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. | Concentration : 1 mg/mL (determined by Absorbance at 280 nm) | Storage Buffer : Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol