Recombinant Human FGFR2 Protein

Specification :
| Description : The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. | Source : E. coli | Species : Human | Form : Lyophilized | Molecular Mass : 19.3 kDa | Protein Length : 821 | AA Sequence : MVSWGRFICLVVVTMATLSLARPSF SLVEDTTLEPEEPPTKYQISQPEVY VAAPGESLEVRCLLKDAAVISWTKD GVHLGPNNRTVLIGEYLQIKGATPR DSGLYACTASRTVDSETWYFMVNVT DAISSGDDEDDTDGAEDFVSENSNN KRAPYWTNTEKMEKRLHAVPAANTV KFRCPAGGNPMPTMRWLKNGKEFKQ EHRIGGYKVRNQHWSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVE RSPHRPILQAGLPANASTVVGGDVE FVCKVYSDAQPHIQWIKHVEKNGSK YGPDGLPYLKVLKAAGVNTTDKEIE VLYIRNVTFEDAGEYTCLAGNSIGI SFHSAWLTVLPAPGREKEITASPDY LEIAIYCIGVFLIACMVVTVILCRM KNTTKKPDFSSQPAVHKLTKRIPLR RQVTVSAESSSSMNSNTPLVRITTR LSSTADTPMLAGVSEYELPEDPKWE FPRDKLTLGKPLGEGCFGQVVMAEA VGIDKDKPKEAVTVAVKMLKDDATE KDLSDLVSEMEMMKMIGKHKNIINL LGACTQDGPLYVIVEYASKGNLREY LRARRPPGMEYSYDINRVPEEQMTF KDLVSCTYQLARGMEYLASQKCIHR DLAARNVLVTENNVMKIADFGLARD INNIDYYKKTTNGRLPVKWMAPEAL FDRVYTHQSDVWSFGVLMWEIFTLG GSPYPGIPVEELFKLLKEGHRMDKP ANCTNELYMMMRDCWHAVPSQRPTF KQLVEDLDRILTLTTNEEYLDLSQP LEQYSPSYPDTRSSCSSGDDSVFSP DPMPYEPCLPQYPHINGSVKT | Purity : > 97% | Applications : WB; ELISA; FACS; FC | Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. | Storage : 4°C | Concentration : 1 mg/mL | Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution (reconst). | Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.