Active Recombinant Human FCGR3A, His & AVI Tagged, Biotinylated, 176 Phe

Specification :
| Description : Receptors for the Fc region of immunoglobin G (Fcγ R) are divided into three classes and CD16 (Fcγ RIII) is a multifunctional, low/intermediate affinity receptor. In human, CD16 is expressed as two distinct forms (CD16a and CD16b) encoded by two different highly homologous genes in a cell type-specific manner. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed by a subset of T lymphocytes, natural killer (NK) cells, monocytes, and macrophages. CD16a has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and delivers an activation signal in the immune responses. | Source : Human Cells | Species : Human | Tag : His & AVI Tag | Form : Lyophilized from sterile PBS , pH 7.4 | Bio-activity : Measured by its ability to bind recombinant human IgG1 in a functional ELISA. | Molecular Mass : The secreted recombinant human CD16a consists of 223 amino acids and predicts a molecular mass of 25.1 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 48 kDa due to glycosylation. | Protein length : Met1-Gln208 | Endotoxin : | Purity : >90 % as determined by SDS-PAGE | Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. | Reconstitution : Reconstitute with water to desired concentration.