Recombinant Human FLT3 Protein, His-tagged

Specification :
| Description : This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. | Source : Human Cells | Species : Human | Tag : His | Form : Purified protein formulated in a sterile solution of TBS buffer, pH7.278, without any preservatives. | Molecular Mass : 112.7 kDa | Endotoxin : Endotoxin level is | Purity : >90% by SDS-PAGE gel and Coomassie Blue staining | Applications : Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies.