Name :
Recombinant Human GSK3B Protein, His-tagged
Specification :
| Description : GSK3B, also known as glycogen synthase kinase-3 beta, acts as a negative regulator in the hormonal control of glucose homeostasis. Also, this protein has diverse functions as Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. | Source : Insect cell | Species : Human | Tag : His | Form : Liquid. In Phosphate Buffered Saline (pH7.4) containing 0.5mM PMSFand 30% glycerol. | Molecular Mass : 47.5kDa (426aa)40-57KDa (SDS-PAGE under reducing conditions.) | AA Sequence : MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST HHHHHH | Endotoxin : | Purity : >90% by SDS – PAGE | Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. | Concentration : 0.25 mg/ml (determined by Absorbance at 280nm)
Gene Information :
| Gene Name : GSK3B glycogen synthase kinase 3 beta [ Homo sapiens ] | Official Symbol : GSK3B | Synonyms : GSK3B; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B; | Gene ID : 2932 | mRNA Refseq : NM_001146156 | Protein Refseq : NP_001139628 | MIM : 605004 | UniProt ID : P49841 | Chromosome Location : 3q13.3 | Pathway : AKT phosphorylates targets in the cytosol, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Aurora A signaling, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; | Function : ATP binding; NF-kappaB binding; RNA polymerase II transcription factor binding; beta-catenin binding; kinase activity; nucleotide binding; p53 binding; protein binding; protein kinase A catalytic subunit binding; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; ubiquitin protein ligase binding;
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