Recombinant Human ICAM3 Protein, C-His-tagged

Specification :
| Description : Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth. These proteins are thought to play an important role in embryogenesis and development. ICAM-3, also designated CD50 and ICAM-R, is a type I membrane protein that is thought to regulate morphological changes during cell locomotion. ICAM-3 acts as a counter-receptor for the leukocyte Integrin αL/β2, and is known to activate T cells and polymorphonuclear leukocytes. ICAM-3 also binds to Moesin, via the cytoplasmic domain of ICAM-3. The expression of ICAM-3 is induced by RANTES, a chemoattractant known to activate T lymphocytes. ICAM-3 is also a major ligand for the leukocyte Integrin LFA-1 (CD11a/CD18). | Source : E. coli | Species : Human | Tag : C-His | Molecular Mass : ~50 kDa | AA Sequence : QEFLLRVEPQNPVLSAGGSLFVNCS TDCPSSEKIALETSLSKELVASGMG WAAFNLSNVTGNSRILCSVYCNGSQ ITGSSNITVYRLPERVELAPLPPWQ PVGQNFTLRCQVEDGSPRTSLTVVL LRWEEELSRQPAVEEPAEVTATVLA SRDDHGAPFSCRTELDMQPQGLGLF VNTSAPRQLRTFVLPVTPPRLVAPR FLEVETSWPVDCTLDGLFPASEAQV YLALGDQMLNATVMNHGDTLTATAT ATARADQEGAREIVCNVTLGGERRE ARENLTVFSFLGPIVNLSEPTAHEG STVTVSCMAGARVQVTLDGVPAAAP GQPAQLQLNATESDDGRSFFCSATL EVDGEFLHRNSSVQLRVLYGPKIDR ATCPQHLKWKDKTRHVLQCQARGNP YPELRCLKEGSSREVPVGIPFFVNV THNGTYQCQASSSRGKYTLVVVMDI EAGSSH | Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). | Notes : For research use only, not for use in diagnostic procedure. | Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. | Concentration : ≥0.5 mg/mL | Storage Buffer : PBS, 4M Urea, pH7.4