Product Name :
NecroX-5
Description:
NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.
CAS:
1383718-29-3
Molecular Weight:
645.81
Formula:
C27H39N3O9S3
Chemical Name:
4-[(7-[(oxan-4-yl)methyl]amino-2-phenyl-1H-indol-5-yl)methyl]-1λ⁶-thiomorpholine-1,1-dione; bis(methanesulfonic acid)
Smiles :
CS(O)(=O)=O.CS(O)(=O)=O.O=S1(=O)CCN(CC2C=C(NCC3CCOCC3)C3NC(=CC=3C=2)C2C=CC=CC=2)CC1
InChiKey:
ZWWWDIWEZYRVMB-UHFFFAOYSA-N
InChi :
InChI=1S/C25H31N3O3S.2CH4O3S/c29-32(30)12-8-28(9-13-32)18-20-14-22-16-23(21-4-2-1-3-5-21)27-25(22)24(15-20)26-17-19-6-10-31-11-7-19;2*1-5(2,3)4/h1-5,14-16,19,26-27H,6-13,17-18H2;2*1H3,(H,2,3,4)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.Telisotuzumab References |Product information|CAS Number: 1383718-29-3|Molecular Weight: 645.Eliglustat supplier 81|Formula: C27H39N3O9S3|Chemical Name: 4-[(7-[(oxan-4-yl)methyl]amino-2-phenyl-1H-indol-5-yl)methyl]-1λ⁶-thiomorpholine-1,1-dione; bis(methanesulfonic acid)|Smiles: CS(O)(=O)=O.PMID:32119328 CS(O)(=O)=O.O=S1(=O)CCN(CC2C=C(NCC3CCOCC3)C3NC(=CC=3C=2)C2C=CC=CC=2)CC1|InChiKey: ZWWWDIWEZYRVMB-UHFFFAOYSA-N|InChi: InChI=1S/C25H31N3O3S.2CH4O3S/c29-32(30)12-8-28(9-13-32)18-20-14-22-16-23(21-4-2-1-3-5-21)27-25(22)24(15-20)26-17-19-6-10-31-11-7-19;2*1-5(2,3)4/h1-5,14-16,19,26-27H,6-13,17-18H2;2*1H3,(H,2,3,4)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 170 mg/mL (263.24 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NecroX-5 (10 or 40 μM) inhibits breast cancer cell migration, which is correlated with mitoROS reduction, and mediated by AKT inhibition. NecroX-5 (10 μM) decreases intracellular calcium concentration in 4T1 cells by blocking Ca2+ influx, which mediated the inhibition of cell migration, AKT downregulation and the reduction of mitochondrial ROS levels. NecroX-5 (10 µM) treatment for 24 h, effectively decreases the increased TNFα, TGFβ1, pSmad2 and the expression of Dcn in LPS-stimulated H9C2 cells.|In Vivo:|NecroX-5 (2.5 mg/kg, everyday other day) inhibits breast cancer cell metastasis in TUBO-P2J tumour-bearing mice.|Products are for research use only. Not for human use.|
