G InformationText S1 A file containing three supplementary figures, aderivation on the remedy for KFP applied to a linear metabolic pathway, a discussion on applying (r)KFP to metabolic cycles, the description of an analytical approach to studying the effects of removing metabolites and pathways, and effects of pathwayAuthor ContributionsConceived and designed the experiments: LH JWL. Performed the experiments: DK XL. Analyzed the data: LH. Wrote the paper: LH JWL CRM.Each year, two million new individuals are diagnosed with cardiovascular disease worldwide 1. Individuals living with that chronic condition, in addition to cautious monitoring of their overall health status, want emotional assistance to cope with complications tough to treat. Within this context, well being social networks2 are virtual environments exactly where on-line assistance groups HS-173 manufacturer constitute an alternative aimed at creating relationships between individuals with comparable interests (Figure 1).MethodsBecause this study concentrate on cardiac disease, a systematic overview with the literature was carried out with articles published from 2007 to 2012 and collected in the following databases: PubMed; (ACM) and (IEEE). The search for scientific articles was restricted to those assessing the usage of `health social networks’ by persons with cardiovascular complications, but no result was obtained together with the expression `health social networks’. Hence, the keyword `online help groups’ was employed.KeywordsCardiovascular Illnesses; Social Network; Discussion Forums; Information and facts Services; Information and facts Exchange.Mailing Address: Edhelmira Lima Medina Av. Visconde do Rio Branco, 51, Centro. Postal Code 24020-000,Niter , RJ – Brasil E-mail: [email protected], [email protected] Manuscript received December ten, 2012; revised manuscript December 19, 2012; accepted March 14, 2013.DOI: 10.5935/abc.ITU – International Telecommunication Union (report “Trends in Telecommunication Reform”). comScore – http://www.comscore.com/ – specialized in measuring the digital globe and digital marketing and advertising intelligence – accessed in October 2012. ACM (Association for Computing Machinery). IEEE (Institute of Electrical and Electronic Engineer) are relevant references within the areas related to Computing ScienceeMedina et al. Health social networksClinical Updateserver Online Connection DevicesdatabaseBlogs Wikis Comments Messages Social NetworkPatientTimeline InteractionsModeratorFigure 1 General model of a social health network.The following terms had been searched: social network; assistance groups; virtual communities; and on the internet patient social network. They were searched isolated or linked using the following overall health PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20178013 descriptors which might be a part of the Healthcare Topic Headings (MeSH) vocabulary: heart; cardiac failure; cardiovascular illness; hypertension individuals; and wellness. Inside the PubMed database, the search was performed solely with all the terms `online assistance groups’ and `health virtual communities’, with no association with other descriptors, simply because PubMed is usually a database on life sciences and biomedical subjects. In IEEEXplore, the terms `social network’ and `health online’ have been utilized for the search. Within the ACM database, all descriptors were searched and related so that the significant term, `online help groups’, was combined with all the following well being descriptors: illnesses; medicine; sufferers; heart; and wellness. The exclusion criteria comprised articles with incomplete information and articles not associated to cardiovascular ailments.HeartNet website A pioneer study on the.
